Sin
"If you do what is right, will you not be accepted? But if you do not do what is right, sin is crouching at your door; it desires to have you, but you must master it" Genesis 4:7.
"...with man this is impossible, but not with God; all things are possible with God" Mark 10:27.
Sin is sin is sin...that which is outside God's will, God's purpose for God's creation and those made in the image of God. The challenge for the 21st century Church, in many ways, is no different than that which faced the 1st century Church, "What are those thoughts/actions that are right, that are in keeping with God's desire, and what are those thoughts/actions that are outside God's will?"
What is your source, your authority for determining God's will?